Drugs used in the CHF

1.       The non-glycoside positive ionotropic drugs is:

a)       Digoxin

b)       Strophantin K

c)       Dobutamine

d)       Digitoxin

2.       This drug inhibits breakdown of cAMP in vascular smooth muscle:

a)       Digoxin

b)       Dobutamine

c)       Amrinone

d)       Dopamine

3.       Mechanism of action of digitalis is:

a)       Inhibits Na⁺ K⁺ ATPase

b)       Inhibit Na⁺ H⁺ ATPase

c)       Active metabolites are produced in the liver

d)       Inhibits calcium concentration in blood

4.       Digitalis acts in atrial fibrillation by:

a)       Increasing AV node refractoriness

b)       Decreasing atrial contractility

c)       Inhibiting Na⁺ K⁺ ATPase

d)       Inhibiting Na⁺ H⁺ ATPase

5.       Digoxin toxicity is increased by all EXCEPT:

a)       Renal impairment

b)       Hyperkalemia

c)       Hypercalcemia

d)       Hypomagnesemia

6.       Cardiac glycoside consist of:

a)       Amino acids and sugar

b)       A steroid combined with sugar residue

c)       A polypeptide and sugar

d)       None of the above

7.       Digoxin differs from Digitoxin in that Digoxin:

a)       Has a longer half life

b)       Is completely absorbed from the GI tract

c)       Is bound extensively to plasma proteins

d)       Its half-life is more dependent on the adequacy of renal function

8.       Digitalis toxicity produce the following change in ECG EXCEPT:

a)       Inverted T wave

b)       Prolonged QT interval

c)       ST depression

d)       Prolonged PR interval

9.       Digoxin toxicity can be precipitated by all EXCEPT:

a)       Phenytoin

b)       Quinidine

c)       Calcium

d)       Verapamil

10.    Drugs most commonly used in chronic heart failure are:

a)       Cardiac glycoside

b)       Diuretics

c)       ACE inhibitor

d)       All the above

11.    The following type of vasodilator is not beneficial in CHF due to systolic dysfunction:

a)       Calcium channel blocker

b)       Angiotensin converting enzyme inhibitor

c)       Nitrate

d)       Hydralazine

12.    The following drug is used for short-term control of emergency heart failure, but not for long-term treatment of congestive heart failure:

a)       Digoxin

b)       Ramipril

c)       Dobutamine

d)       Spironolactone

13.    What is heart failure?

a)       A condition in which heart stops beating

b)       A condition in which the heart cannot pump enough blood to meet the body’s needs

c)       A condition in which the patient experiences chest pain

d)       A heart attack

14.    Which of the following is not a sign of ride sided congestive heart failure?

a)       Prominent jugular vein

b)       Hepatomegaly

c)       Pulmonary edema

d)       Pleural effusion

15.    Which one of the following is not heart failure?

a)       Right-sided heart failure

b)       Left-sided heart failure

c)       Myocardial heart failure

d)       Congestive heart failure

16.    Which of the following is NOT an inotropic drug:

a)       Dopamine

b)       Isoprenaline

c)       Amrinone

d)       Amiodarone

17.    Which of the following is primarily a venodilator?

a)       Hydralazine

b)       Minoxidil

c)       Nitroprusside

d)       Nifedipine 

18.    Potassium therapy tends to counteract the cardiac toxicity of digitalis by:

a)       Reducing the affinity of sarcolemma Na⁺ K⁺ ATPase for digitalis

b)       Suppressing ectopic automaticity enhanced by digitalis

c)       Promoting A-V conduction

d)       Both ‘A’ and ‘B’ are correct

19.    Which of the following is NOT indicated in Digitalis poisoning:

a)       Potassium

b)       Hemodialysis

c)       Phenytoin

d)       Lidocaine

20.    The most cardiac manifestation of glycoside intoxication is:

a)       Atrioventricular junction rhythm

b)       Second-degree atrioventricular blockage

c)       Ventricular tachycardia

d)       All the above

 Answer