Pharmacology Drugs Classification

Drugs acting on autonomic nervous system

Cholinergic drugs (Parasympathomimetic)

Cholinergic agonist

A.      Cholinester

·         Acetylcholine

·         Carbachol

·         Bethanechol

·         Methacholine  

B.      Alkaloids

·         Muscarine

·         Pilocarpine

·         Arecholine

Anti-cholinesterase

A.      Reversible

a)       Carbamate

·   Physostigmine (Eserine)

·   Neostigmine

·   Pyridostigmine

·   Rivastigmine

·   Edrophonium

·   Donepezil

·   Galantamine

b)      Acridine

·   Tacrine

B.      Irreversible

a)       Organophosphates

·   Dyflos (DFP)

·   Echothiophate

·   Malathion

·   Diazinon

·   Tabun, serine, soman

b)      Carbamates

·   Carbaryl (Sevin)

·   Propoxur (Baygon)            

Anticholinergic drugs (Para-sympatholytic)

A.      Natural alkaloids

·         Atropine

·         Hyoscine (Scopolamine)

B.      Semisynthetic derivatives

·         Homatropine

·         Atropine methonitrate

·         Hyoscine butyl bromide

·         Ipratropium bromide

·         Tiotropium bromide

C.      Synthetic derivatives

a)       Mydriatics

·         Cyclopentolate

·         Tropicamide

b)      Vasicoselective

·         Oxybutynin

·         Flavoxate

·         Tolterodine

c)       Anti-parkinsonism

·         Trihexyphenidyl (Benzhexol)

·         Procyclidine

·         Bipiridine

d)      Anti-secretory – Anti-spasmodic

                                 i.            Quaternary compound

·         Propantheline

·         Pipenzolate methyl bromide

·         Isopropamide

·         Glycopyrolate

·         Oxyphenonium

·         Clindinum

                               ii.            Tertiary compound

·         Dicyclomine

·         Valethamate

·         Pirenzepine  

Ganglionic stimulants

A.      Selective nicotinic agonists

·         Nicotine

·         Lobeline

·         Dimethyl phenyl piperazinum (DMPP)

·         Tetramethyl ammonium (TMA)

·         Varenicline

B.      Nonselective/Muscarinic agonists

·         Acetylcholine

·         Carbachol

·         Pilocarpine

·         Anti-cholinesterases

Ganglionic blocking agents

A.      Competitive blockers

                                 i.            Quaternary ammonium compounds

·   Hexamethonium

·   Pentolinium

                               ii.            Amines

·   Mecamylamine

·   Pempidine  

                             iii.            Monosulphonium compounds

·   Trimethaphan

·   Camforsulfonate

B.      Persistent depolarizing blockers

·         Nicotine

·         Anticholinesterase  

Adrenergic drugs (Sympathomimetics)

A.      Pressor agents

·         Noradrenaline

·         Epinephrine

·         Dopamine

·         Phenylephrine

·         Methoxamine

·         Mephentermine

B.      Bronchodilator

·         Isoprenaline

·         Salbutamol (Albuterol)

·         Terbutaline

·         Salmeterol

·         Formeterol

·         Bambuterol

C.      CNS stimulants

·         Amphetamine

·         Dexamphetamine  

·         Methamphetamine  

·         Methylphenidate

D.      Uterine relaxant

·         Ritodrine

·         Isoxsuprine

·         Salbutamol

·         Terbutaline

E.      Cardiac stimulant

·         Adrenaline

·         Isoprenaline

·         Dobutamine

F.       Nasal decongestant

·         Xylometazoline

·         Oxymetazoline

·         Naphazoline

·         Phenylephrine

·         Phenylpropanolamine

G.     Anorectics

·         Amphetamine

·         Phenfluramine

·         Dexfenfluramine

·         Sibutramine

α-adrenergic blocking agents

Equilibrium types (Competitive antagonist)

A.      Non selective

                                 i.            Ergot alkaloid

·   Ergotamine

·   Ergotoxine

                               ii.            Hydrogenated ergot alkaloid

·   Dihydroergotamine (DHE)

·   Dihydroergotoxine

                             iii.            Imidazoline

·   Phentolamine

                             iv.            Miscellaneous

·   Chlorpromazine

B.      α₁ selective

·         Prazosin

·         Terazosin

·         Doxazosin

·         Alfuzosin

·         Tamsulosin

C.      α₂ selective

·         Yohimbine

Non-equilibrium types

A.      β-alkylamin

·         Phenoxybenzamine  

β-adrenergic blocking agents

A.      Non-selective (β₁ + β₂)

                                 i.            Without intrinsic sympathomimetic activity

·   Propranolol

·   Sotalol

·   Timolol

                               ii.            With intrinsic sympathomimetic activity

·   Pindolol

                             iii.            With α blocking property

·   Labetalol

·   Carvedilol

B.      Cardio-selective (β₁)

·         Metoprolol

·         Atenolol

·         Acebautolol

·         Bisoprolol

·         Esmolol

·         Betaxolol

·         Celiprolol

·         Nebivolol