Autonomic Nervous System (ANS) MCQ

1)       Acetylcholine is not a specific neurotransmitter at:

a)       Sympathetic ganglia

b)       Sympathetic ganglionic nerve endings

c)       Parasympathetic ganglia

d)       Parasympathetic postganglionic nerve endings.

2)       Muscarinic receptor are located in:

a)       Autonomic ganglia

b)       Skeletal muscle neuromuscular junctions

c)       Autonomic effector cells

d)       Sensory carotid sinus baroreceptor zone

3)       Location of M₂ cholinoreceptor:

a)       Heart

b)       Glands

c)       Smooth muscle

d)       Endothelium

4)       The symptoms of mushroom poisoning including all of the following EXCEPT:

a)       Salivation, Lacrimation, Nausea, Vomiting

b)       Dryness of mouth,  hyperpyrexia, hallucination

c)       Headache, abdominal colic

d)       Bradycardia, hypotension and shock

5)       Action of Pilocarpine include the following EXCEPT:

a)       Sweating

b)       Salivation

c)       Miosis

d)       Cycloplegia

6)       Cholinergic muscarinic receptor stimulation produces the following effects EXCEPT:

a)       Sweating

b)       Rise in BP

c)       Bradycardia

d)       Urination

7)       Indicate a reversible cholinesterase inhibitor:

a)       Isoflurophate

b)       Carbachol

c)       Pysostigmine

d)       Parathion 

8)       Which of the following properties make Pyridostigmine different from neostigmine?

a)       It is more potent orally

b)       It is longer acting

c)       It produces less muscarinic side effects

d)       It does not any direct action on N_N receptor

9)       The choline esterase resistant to both true and pseudo cholinesterase is:

a)       Methacholine

b)       Bethanechol

c)       Benzoylcholine

d)       Buryrylcholine

10)   Which of the following cholinomimetics is indirect-acting?

a)       Lobeline

b)       Edrophonium

c)       Pilocarpine

d)       Carbachol

11)   Which of the following is a relatively cerebroselective anticholinesterase found to afford symptomatic improvement in Alzheimer’s disease.

a)       Donepezil

b)       Gemflbrozil

c)       Pyridostigmine

d)       Pyritionol

12)   The mechanism action of indirect acting cholinomimetics agents is:

a)       Binding to and activation of muscarinic and nicotinic receptor.

b)       Inhibition of the hydrolysis of endogenous acetylcholine.

c)       Stimulation of the action of acetyl-cholinesterase.

d)       Releasing acetylcholine from storage sites.

13)   The following is an α₂ adrenergic agonist used as eye drops to lower IOP:

a)       Brinzolamide

b)       Bambuterol

c)       Brimonidine

d)       Latanoprost

14)   Which of the following provide the best explanation for neostigmine being preferred over Pysostigmine for treating myasthenia gravis?

a)       It is better absorbed orally

b)       It has longer duration of action

c)       It has longer direct agonistic action on nicotinic receptors at the muscle end plate

d)       It penetrate BBB

15)   Treatment of atropine toxicity-

a)       2-pralidoxime

b)       Naloxone

c)       Flumazenil

d)       Pysostigmine

16)   Edrophonium is more suitable for differentiating myasthenic crisis from cholinergic crisis because of its:

a)       Shorter duration of action

b)       Longer duration of action

c)       Direct action on muscle end plate

d)       Selective inhibition of true cholinesterase

17)   Which of the following organ innervated only by parasympathetic nerves:

a)       Iris muscles

b)       Ciliary muscle

c)       Sweat glands

d)       Splenic gland

18)   The toxic effects of a large dose of nicotine includes all the following EXCEPT:

a)       Hypotension and Bradycardia

b)       Convulsions, coma and respiratory arrest

c)       Skeletal muscle depolarization blockade and respiratory paralysis

d)       Hypertension and cardiac arrhythmia.

19)   Which of the following properties make Pyridostigmine different form Neostigmine?

a)       It is more potent orally

b)       It is longer acting

c)       It produce less muscarinic side effects

d)       It does not any direct action on N_M receptors

20)   Which of the following drugs is used for acute toxic effects of organophosphate cholinesterase inhibitors?

a)       Atropine

b)       Pilocarpine

c)       Pralidoxime

d)       Edrophonium

21)   Select the diuretic that is most effective in acute congestive glaucoma:

a)       Indapamide

b)       Amiloride

c)       Mannitol

d)       Furosemide 

22)   Which of the most important drug in the treatment of organophosphate poisoning:

a)       Atropine sulfate

b)       Pralidoxime

c)       Diazepam

d)       Adrenaline

23)   Dorzolamide is a:

a)       Topical applied ocular carbonic anhydrase inhibitor

b)       Second generation sulfonylurea hypoglycemic

c)       Topical sulfonamide antibacterial

d)       Luminal amoebicide

24)   A direct acting cholinomimetic that is lipid soluble and has been used in the treatment of glaucoma is:

a)       Acetylcholine

b)       Physostigmine

c)       Pilocarpine

d)       Neostigmine

25)   Drugs of choice for treatment of acute organophosphate poisoning is:

a)       Atropine

b)       Pralidoxime

c)       Neostigmine

d)       d- Tubocurarine

26)   The neurotransmitter agent that is normally released in the SA node of the heart in response to increased blood pressure is:

a)       Acetylcholine

b)       Dopamine

c)       Adrenaline

d)       Noradrenaline

27)   Bethanechol has all the following properties EXCEPT:

a)       It is extremely resistant to hydrolysis

b)       Purely Muscarinic in its action

c)       It is used for abdominal urinary bladder distention

d)       It exerts both nicotinic and muscarinic effects

28)   Neostigmine is not able to cross BBB because of its:

a)       Primary structure

b)       Secondary structure

c)       Tertiary structure

d)       Quaternary structure

29)   Teat for myasthenia gravis is:

a)       Succinylcholine

b)       Ameliorative test

c)       Provocative test

d)       Both b & c

30)   The drug of choice for mushroom poisoning is:

a)       Adrenaline

b)       Physostigmine

c)       Atropine

d)       Carbachol

31)   The most effective antidote for belladonna poisoning is:

a)       Neostigmine

b)       Physostigmine

c)       Pilocarpine

d)       Methacholine

32)   Which of the following is a ganglion-blocking drug?

a)       Homatropine

b)       Hexamethonium

c)       Rapacuronium

d)       Edrophonium

33)   All of the following agents are used in glaucoma treatment, EXCEPT:

a)       Apraclonidine

b)       Timolol

c)       Pilocarpine

d)       Metoprolol

34)   Which of the following anticholinergic drugs is primarily used in pre-anaesthetic medication and during surgery:

a)       Glycopyrolate

b)       Pipenzolate methyl bromide

c)       Isopropamide

d)       Dicyclomine

35)    A patient in emergency with tachycardia, hyperthermia, bronchial dilation and constipation. The person is likely to be suffering from overdose of:

a)       Atropine

b)       Organophosphorus compound

c)       Mushroom

d)       Paracetamol

36)   Botulinum toxin produces skeletal muscle paralysis by:

a)       Enhancing release of nor-epinephrine

b)       Inhibiting release of acetylcholine

c)       Direct damage to nerve ending

d)       Producing hemolysis

37)   Which of the following drugs is useful in the treatment of Parkinson’s disease?

a)       Benztropine

b)       Edrophonium

c)       Succinylcholine

d)       Hexamethonium

38)   Atropine mechanism action in organophosphate poisoning:

a)       Reactivation of choline esterase

b)       Acts on central and peripheral post ganglionic receptor

c)       Acts on central and peripheral cholinergic receptors

d)       Acts on peripheral cholinergic receptors only