1) Acetylcholine is not a specific neurotransmitter at:
a) Sympathetic ganglia
b) Sympathetic ganglionic nerve endings
c) Parasympathetic ganglia
d) Parasympathetic postganglionic nerve endings.
2) Muscarinic receptor are located in:
a) Autonomic ganglia
b) Skeletal muscle neuromuscular junctions
c) Autonomic effector cells
d) Sensory carotid sinus baroreceptor zone
3) Location of M2 cholinoreceptor:
a) Heart
b) Glands
c) Smooth muscle
d) Endothelium
4) The symptoms of mushroom poisoning including all of the following EXCEPT:
a) Salivation, Lacrimation, Nausea, Vomiting
b) Dryness of mouth, hyperpyrexia, hallucination
c) Headache, abdominal colic
d) Bradycardia, hypotension and shock
5) Action of Pilocarpine include the following EXCEPT:
a) Sweating
b) Salivation
c) Miosis
d) Cycloplegia
6) Cholinergic muscarinic receptor stimulation produces the following effects EXCEPT:
a) Sweating
b) Rise in BP
c) Bradycardia
d) Urination
7) Indicate a reversible cholinesterase inhibitor:
a) Isoflurophate
b) Carbachol
c) Pysostigmine
d) Parathion
8) Which of the following properties make Pyridostigmine different from neostigmine?
a) It is more potent orally
b) It is longer acting
c) It produces less muscarinic side effects
d) It does not any direct action on NN receptor
9) The choline esterase resistant to both true and pseudo cholinesterase is:
a) Methacholine
b) Bethanechol
c) Benzoylcholine
d) Buryrylcholine
10) Which of the following cholinomimetics is indirect-acting?
a) Lobeline
b) Edrophonium
c) Pilocarpine
d) Carbachol
11) Which of the following is a relatively cerebroselective anticholinesterase found to afford symptomatic improvement in Alzheimer’s disease.
a) Donepezil
b) Gemflbrozil
c) Pyridostigmine
d) Pyritionol
12) The mechanism action of indirect acting cholinomimetics agents is:
a) Binding to and activation of muscarinic and nicotinic receptor.
b) Inhibition of the hydrolysis of endogenous acetylcholine.
c) Stimulation of the action of acetyl-cholinesterase.
d) Releasing acetylcholine from storage sites.
13) The following is an α2 adrenergic agonist used as eye drops to lower IOP:
a) Brinzolamide
b) Bambuterol
c) Brimonidine
d) Latanoprost
14) Which of the following provide the best explanation for neostigmine being preferred over Pysostigmine for treating myasthenia gravis?
a) It is better absorbed orally
b) It has longer duration of action
c) It has longer direct agonistic action on nicotinic receptors at the muscle end plate
d) It penetrate BBB
15) Treatment of atropine toxicity-
a) 2-pralidoxime
b) Naloxone
c) Flumazenil
d) Pysostigmine
16) Edrophonium is more suitable for differentiating myasthenic crisis from cholinergic crisis because of its:
a) Shorter duration of action
b) Longer duration of action
c) Direct action on muscle end plate
d) Selective inhibition of true cholinesterase
17) Which of the following organ innervated only by parasympathetic nerves:
a) Iris muscles
b) Ciliary muscle
c) Sweat glands
d) Splenic gland
18) The toxic effects of a large dose of nicotine includes all the following EXCEPT:
a) Hypotension and Bradycardia
b) Convulsions, coma and respiratory arrest
c) Skeletal muscle depolarization blockade and respiratory paralysis
d) Hypertension and cardiac arrhythmia.
19) Which of the following properties make Pyridostigmine different form Neostigmine?
a) It is more potent orally
b) It is longer acting
c) It produce less muscarinic side effects
d) It does not any direct action on NM receptors
20) Which of the following drugs is used for acute toxic effects of organophosphate cholinesterase inhibitors?
a) Atropine
b) Pilocarpine
c) Pralidoxime
d) Edrophonium
21) Select the diuretic that is most effective in acute congestive glaucoma:
a) Indapamide
b) Amiloride
c) Mannitol
d) Furosemide
22) Which of the most important drug in the treatment of organophosphate poisoning:
a) Atropine sulfate
b) Pralidoxime
c) Diazepam
d) Adrenaline
23) Dorzolamide is a:
a) Topical applied ocular carbonic anhydrase inhibitor
b) Second generation sulfonylurea hypoglycemic
c) Topical sulfonamide antibacterial
d) Luminal amoebicide
24) A direct acting cholinomimetic that is lipid soluble and has been used in the treatment of glaucoma is:
a) Acetylcholine
b) Physostigmine
c) Pilocarpine
d) Neostigmine
25) Drugs of choice for treatment of acute organophosphate poisoning is:
a) Atropine
b) Pralidoxime
c) Neostigmine
d) d- Tubocurarine
26) The neurotransmitter agent that is normally released in the SA node of the heart in response to increased blood pressure is:
a) Acetylcholine
b) Dopamine
c) Adrenaline
d) Noradrenaline
27) Bethanechol has all the following properties EXCEPT:
a) It is extremely resistant to hydrolysis
b) Purely Muscarinic in its action
c) It is used for abdominal urinary bladder distention
d) It exerts both nicotinic and muscarinic effects
28) Neostigmine is not able to cross BBB because of its:
a) Primary structure
b) Secondary structure
c) Tertiary structure
d) Quaternary structure
29) Teat for myasthenia gravis is:
a) Succinylcholine
b) Ameliorative test
c) Provocative test
d) Both b & c
30) The drug of choice for mushroom poisoning is:
a) Adrenaline
b) Physostigmine
c) Atropine
d) Carbachol
31) The most effective antidote for belladonna poisoning is:
a) Neostigmine
b) Physostigmine
c) Pilocarpine
d) Methacholine
32) Which of the following is a ganglion-blocking drug?
a) Homatropine
b) Hexamethonium
c) Rapacuronium
d) Edrophonium
33) All of the following agents are used in glaucoma treatment, EXCEPT:
a) Apraclonidine
b) Timolol
c) Pilocarpine
d) Metoprolol
34) Which of the following anticholinergic drugs is primarily used in pre-anaesthetic medication and during surgery:
a) Glycopyrolate
b) Pipenzolate methyl bromide
c) Isopropamide
d) Dicyclomine
35) A patient in emergency with tachycardia, hyperthermia, bronchial dilation and constipation. The person is likely to be suffering from overdose of:
a) Atropine
b) Organophosphorus compound
c) Mushroom
d) Paracetamol
36) Botulinum toxin produces skeletal muscle paralysis by:
a) Enhancing release of nor-epinephrine
b) Inhibiting release of acetylcholine
c) Direct damage to nerve ending
d) Producing hemolysis
37) Which of the following drugs is useful in the treatment of Parkinson’s disease?
a) Benztropine
b) Edrophonium
c) Succinylcholine
d) Hexamethonium
38) Atropine mechanism action in organophosphate poisoning:
a) Reactivation of choline esterase
b) Acts on central and peripheral post ganglionic receptor
c) Acts on central and peripheral cholinergic receptors
d) Acts on peripheral cholinergic receptors only
Answer
1-b | 2-c | 3-a | 4-b | 5-d | 6-b | 7-c | 8-b | 9-b | 10-a |
11-a | 12-b | 13-c | 14-c | 15-d | 16-a | 17-b | 18-a | 19-b | 20-c |
21-c | 22-a | 23-a | 24-c | 25-a | 26-a | 27-d | 28-d | 29-d | 30-c |
31-b | 32-b | 33-d | 34-a | 35-a | 36-b | 37-a | 38-c |
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Hi…!! This is Smrutiranjan Dash, Assistant Professor of Pharmacology from Odisha, India. With a passion for teaching and a dedication to advancing the field of pharmacology, I am committed to sharing knowledge, fostering innovation, and inspiring future healthcare professionals.
