• Biohemistry

    Tricarboxylic acid cycle/Krebs (TCA) Cycle / Citric acid cycle

    TCA is the most important metabolic pathway for the energy supply to the biological system. About 65-70% of the ATP is synthesized in Krebs cycle. Citric acid cycle essentially involves the oxidation of acetyl CoA to CO2 and H2O Proposed by Hans Adolf Krebs in 1937. Oxygen consumption in pigeon breast muscle. Nobel Prize 1953. The citric acid cycle is the final common oxidative pathway for carbohydrates, fats and amino acids. Reactions of citric acid cycle Oxidative decarboxylation of pyruvate from glycolysis is link between glycolysis and TCA cycle. Convert pyruvate to acetyl CoA by pyruvate dehydrogenase. 1. Formation of citrate The cycle is starts with condensation of acetyl CoA…

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