• Pharmacology

    Eicosanoids (Prostaglandins)

    Eicosanoids Prostaglandin (PGs) and leukotrienes (LTs) are derived from polyunsaturated essential fatty acids with 20 carbon atoms. 1930: Human semen – contracts uterus and other smooth muscles (SM) to cause fall in BP. The prostaglandin was derived from the prostate. 1970: Aspirin like drugs inhibit PG synthesis Thromboxanes (TX) and Prostacyclin (PGI) Bergstrom, Samuelsson and Vane got the Nobel Prize in 1982 for their work on PGs and LTs. Chemistry Chemically, PGs may be considered to be derivatives of prostanoic acid, though prostanoic acid does not naturally occur in the body. PGs are designated in series as – A, B, C ….I etc. depending on ring structure and substitution Each…

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