• Pharmacology

    Autacoid (5-hydroxytryptamine (5-HT, serotonin))

    5-hydroxytryptamine (5-HT, serotonin) Serotonin and enteramine both are 5-hydroxytryptamine, a monoamine neurotransmitter, and are derived from tryptophan. About 90% of the body contains 5-HT is localized in the intestine and the rest are in platelets and the brain. It also found in other animals and plants; Animals: invertebrates and mollusks, arthropods, snake and bee venom/sting. Plants: plants: tomato, pear, banana & pineapple. Synthesis storage and destruction It is synthesized from the amino acid tryptophan. Tryptophan converted to 5-hydroxytryptophan with the help of enzyme hydroxylase. 5-HTP decarboxylase to produce 5-HT. The decarboxylase is non-specific, acts on DOPA as well as 5-hydroxytryptophan (5-HTP) to produce DA and 5-HT respectively. It is degraded…

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